The research interest of the Bianchi lab is to discover the mechanisms regulating protein homeostasis in physiologic and pathologic states of plasma cell differentiation and the role that proteostasis plays in determining plasma cell fate. The overall vision of the lab is to build a strong mechanistic foundation for the development of innovative treatments targeting plasma cell disorders such as AL amyloidosis and multiple myeloma, as well as the progression of precursor diseases monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM).